During a public appearance to a cathedral in Staffordshire on Monday, King Charles was confronted by a protester who questioned him about his brother's links with convicted sex offender Jeffrey Epstein.
The protester inquired how long the monarch had been aware about his sibling's relationship with Epstein, and also raised doubts about whether he had asked the police to "hide" for Prince Andrew.
Amid the protest, there were large groups of fans and applause for the monarch, who was visiting Staffordshire for an ceremony.
Prince Andrew's associations with Jeffrey Epstein have been under close examination in recent weeks. The royal, who relinquished his royal duties earlier this month, has repeatedly denied any misconduct.
"For how long have you known about Andrew and Epstein? Have you asked the police to cover up for Andrew?"
The monarch ignored the questions but continued greeting fans, some of whom chanted "God Save The King". One fan can be overheard asking him for a embrace.
Another woman outside the cathedral was also heard telling the protester to "go away" and to "shut up".
The controversy over Prince Andrew's connections to Epstein has been revived by misconduct allegations repeated in Virginia Giuffre's posthumously-published book.
In the publication, Ms Giuffre claims she had sexual encounters with the prince on multiple times, including one instance with Jeffrey Epstein and "eight other young girls"
Andrew, who reached a out-of-court agreement with the plaintiff in 2022, has repeatedly denied any wrongdoing. In a previous interview, he told a news program he did not remember meeting her "ever", and that they "did not have any sort of sexual contact."
But in recent times, fresh questions have been raised about how he is able to fund his way of life despite not being a active member of the royal family.
The revelation that he has only ever paid a token annual rent on his Windsor mansion has intensified the scrutiny over his living arrangements - even though he made significant contributions up front, including for renovations.
The Liberal Democrats said he should be called in front of members of parliament to give evidence about his lease of his residence.
But last Thursday, the government refused to give parliamentarians time to debate the royal's status or his residence, despite increasing calls for investigation.
The royal household has not issued a statement on whether Prince Andrew might move out of his home - or where he might reside.
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